Medical Assistant Apprenticeship

K Srivastava doctor Medicinal Chemistry Department, CSIR CIMAP, Lucknow U. P, , India Has contributed: QSAR Guided Semi synthesis and In Vitro Validation of Anticancer Activity in Ursolic Acid DerivativesCancer is doctor second most efficient causes of death among non communicable illnesses, and doctor incidenceof cancer has been dramatically greater in doctor past several decades which is especially attributed tolifestyle adjustments . Cancer can be cured by distinctive ideas, and doctor five year relative survivalrate of all cancers has greater considerably in recent years . However, doctor complexity and refractorynature of doctor disorder itself, along with doctor drug resistance, side consequences, and non actual toxicityof chemotherapy agents, calling for constantly innovate doctor development of new cancer treatmentschemes and novel anticancer agents . Indazoles and indoles, bicyclic compounds with fused benzene and pyrazole/pyrrole nucleus, possessremarkable structural and mechanistic range and could exert doctor anticancer exercise via inhibitingDNA topoisomerase, histone deacetylase, histone acetyltransferases, myeloid cell leukemia 1, proviralinsertion site in moloney murine leukemia virus, silent mating type assistance regulation 2 homolog and tubulin . Axitinib, lonidamine and pazopanib are indazole based anticancer agents, whereas vinblastine, vincristine, anlotinib andosimertinib include indole moiety.